The Effect of Tolpa Peat Preparation on the Phagocytic and Metabolic Activity of Neutrophils in Normothermic Rabbits and those with Pyrogen-Induced Fever

Abstract:

The studies on normothermic rabbits show that intravenous administration of Tolpa Peat Preparation (TPP) at a dose of 5 mg/kg for 3 or 6 consecutive days increases the percentage of phagocytizing cells and the number of bacteria phagocytized by a single neutrophil. The stimulated phagocytic activity of neutrophils coincides with increased nitroblue tetrazolium (NBT) reduction. In contrast, a single administration of TPP to rabbits with fever induced by E. coli lipopolysaccharide (LPS) has a modulating effect on the metabolic activity of neutrophils, depending on the TPP dose. TPP administered at a dose of 0.5 mg/kg potentiates the stimulating effect of pyrogen on the percentage of NBT-positive neutrophils. A ten-fold increase of the TPP dose (5 mg/kg) reduces the stimulating effect of LPS, and a hundred-fold increase (50 mg/kg) leads to total inhibition of LPS-induced changes.

Authors:

Obminska-Domoradzka, B.
Switala, M.
Debowy, J.
Garbulinski, T.

Abbreviated Journal Title: Acta Pol Pharm
Date of Publication: 1993
Journal Volume: 50
Page Numbers: 389 through 392
Country of Publication: Poland
Language of Article: English
Issue/Part/Supplement: 4-5
ISSN: 0001-6837

MESH Headings:

Peat Preparation
Metabolic Activity
Phagocytic Capacity

Published with permission from Acta Poloniae Pharmaceutica - Drug Research