Influence of Long-Term Administration of Tolpa Peat Preparation on Immune Reactivity in Mice. I. Morphological Changes in Thymus

Abstract:

In experiment I, 200 BALB/c mice were given TPP (Tolpa Peat Preparation) in drinking water in daily doses of 1, 10, and 50 mg/kg over a period of 3, 5, 7, 9, and 12 weeks. In experiment II, before the administration of TPP (as in experiment I), mice were immunized with a single dose i.p. of 0.2 cm³ of a 10% suspension of sheep erythrocytes (SRBC), i.e. 4x10⁸ cells. Histopathological and ultrastructural studies have shown that in all three doses TPP causes morphological changes characteristic for thymus activity stimulation. However, the doses of 10 and 50 mg/kg administered for more than 7 weeks cause retrograde changes that do not occur after 1 mg/kg of TPP. The morphological changes were similar in the thymus of the immunized and non-immunized mice simultaneously receiving TPP.

Authors:

Madej, J.A.
Kuryszko, J.
Garbulinski, T.

Abbreviated Journal Title: Acta Pol Pharm
Date of Publication: 1993
Journal Volume: 50
Page Numbers: 397 through 404
Country of Publication: Poland
Language of Article: English
Issue/Part/Supplement: 4-5
ISSN: 0001-6837

MESH Headings:

Peat Preparation
Immunoregulation
Histopathological Study

Published with permission from Acta Poloniae Pharmaceutica - Drug Research