Influence of Long-Term Administration of Tolpa Peat Preparation on Immune Reactivity in Mice. III. The Effect on Primary Humoral Response to Sheep Erythrocytes

Abstract:

Tolpa Peat Preparation (TPP) was administered to mice in daily doses of 1, 10, and 50 mg/kg for 3, 5, 7, 9, or 12 consecutive weeks. After each of these periods, the primary response to sheep erythrocytes (SRBC) was examined by assaying the percentage of splenocytes producing anti-SRBC 19S and 7S hemolysins, and the level of serum hemagglutinins to SRBC (19S + 7S). The effect of enhanced humoral response by TPP was observed in the mice immunized with SRBC. This effect depended, first of all, on the TPP dose and on the duration of TPP administration. The stimulating effect on the humoral response occurred after the daily dose of 1 mg/kg over a 12-week period. On the other hand, the daily doses that were 10 or 50 times higher enhanced the humoral response only during the first 5-7 weeks of TPP administration. Longer administration of TPP in these doses caused disappearance of this effect or reduction of the response to SRBC.

Authors:

Obminska-Domoradzka, B.
Debowy, J.
Garbulinski, T.

Abbreviated Journal Title: Acta Pol Pharm
Date of Publication: 1993
Journal Volume: 50
Page Numbers: 491 through 496
Country of Publication: Poland
Language of Article: English
Issue/Part/Supplement: 6
ISSN: 0001-6837

MESH Headings:

Peat Preparation
Spleen-Lymphocytes
Serum Hemagglutinins

Published with permission from Acta Poloniae Pharmaceutica - Drug Research