Influence of Tolpa Peat Preparation (TPP) on Rat Liver Regeneration

Abstract:

The effect of Tolpa Peat Preparation (TPP) on the regenerative response has been examined in rats submitted to two-thirds hepatectomy. The ornithine decarboxylase activity, spermidine and histamine levels, DNA and RNA content, RNA/DNA ratio, and the mass of restituted liver were used to test the intensity of the regenerative processes. The action of TPP is dual: a short-term application of TPP at a dose of 20 mg/kg/day causes an inhibition of the ornithine decarboxylase activity and a decrease in spermidine formation, in the levels of DNA and RNA, and in liver restitution. Multiple applications of TPP, on the other hand, result in a stimulation of ornithine decarboxylase and an increase in spermidine and histamine as well as in RNA and DNA levels in regenerating liver; concomitantly, the liver mass tends to increase in TPP- treated groups. TPP might exert its effects, at least partially, by interfering with polyamine biosynthesis.

Authors:

Maslinski, Cz.
Fogel, A.
Andrzejewski, W.

Abbreviated Journal Title: Acta Pol Pharm
Date of Publication: 1993
Journal Volume: 50
Page Numbers: 413 through 416
Country of Publication: Poland
Language of Article: English
Issue/Part/Supplement: 4-5
ISSN: 0001-6837

MESH Headings:

Peat Preparation
Decarboxylase Activity
Biosynthesis of Polyamines

Published with permission from Acta Poloniae Pharmaceutica - Drug Research