Investigations of Selected Pharmacological Properties of TPP

Abstract:

The experiments were performed on mice, rats and rabbits and included an evaluation of the effect on the circulatory, central nervous and gastrointestinal systems in vivo and in vitro, as well as on renal secretory activity. TPP was administered p.o., i.v. and s.c. at doses 100.0-400.0 mg/kg. Either in a single dose or in multiple doses, TPP did not evoke any significant effects (as compared with NaCl solution) on blood pressure, heart and respiratory rates, general behavior, locomotor activity, body temperature, locomotor coordination, ECoG, smooth muscles of the intestine in vivo and in vitro, gastric secretion, or on the volume and quality of excreted urine. The augmentation of sodium and potassium ion excretion with urine and the slight influence on locomotor coordination after TPP and 6% NaCl seems to be connected with the high salt content of TPP.

Author:

Filczewski, M. et al.

Abbreviated Journal Title: Acta Pol Pharm
Date of Publication: 1992
Journal Volume: 49
Page Numbers: 107 through 113
Country of Publication: Poland
Language of Article: English
Issue/Part/Supplement: 4
ISSN: 0001-6837

MESH Headings:

TPP
Circulatory System
Respiration
Central Nervous System
Gastrointestinal System

Published with permission from Acta Poloniae Pharmaceutica - Drug Research