Influence of Tolpa Peat Preparation on the IgE-induced Anaphylactic Reactions in Mice

Abstract:

The ability of Tolpa Peat Preparation (TPP) to affect anaphylactic sensitization and mast cell secretory function was tested in Balb/c mice treated with TPP orally for 12 days. In the doses of 20 and 50 mg/kg/day, TPP reduced histamine release from mouse peritoneal mast cells challenged with anti-IgE or concavalin A in vitro. The treatment of mice with TPP from day 1 to 12 of immunization with Ovalbumin (OA) adsorbed on aluminum hydroxide gel resulted in a decrease of antigen-induced histamine release from mast cells of these mice in vitro and in a decreased IgE antibody level in their sera. TPP introduced into OA-immunized mice showing developed IgE antibody response was less effective in decreasing anaphylactic histamine release from mast cells of these mice. In all experiments involving oral treatment, low doses of TPP were more effective than high doses in inhibiting anaphylactic events in the mice.

Author:

Wyczolkowska, J.

Abbreviated Journal Title: Acta Pol Pharm
Date of Publication: 1993
Journal Volume: 50
Page Numbers: 475 through 480
Country of Publication: Poland
Language of Article: English
Issue/Part/Supplement: 6
ISSN: 0001-6837

MESH Headings:

Peat Preparation
Anaphylactic Sensitization

Published with permission from Acta Poloniae Pharmaceutica - Drug Research